摘要
miRNA(microRNA)是一类长约22个碱基的内源性非编码小RNA,在调节细胞增殖、分化及多种信号通路中起重要作用.近年发现,miRNA参与调控多种肝病相关基因的表达.在肝癌中有的miRNA能促使癌症的发生,有的能作为抑癌因子起作用,因此miRNA可作为治疗靶点应用于临床.本文对miRNA在肝细胞疾病,如酒精肝损伤、肝炎及肝癌中的研究进展进行综述.
MicroRNAs（miRNAs） are small noncoding RNAs involved in regulating cellular proliferation,differentiation and signaling pathways.Recent researches reveal that miRNAs also play an important role in genes related to hepatic diseases.The different expression profiles of miRNA in hepatocellular carcinoma suggested that miRNA might serve as either novel potential targets acting directly as oncogenes or therapeutic molecular targets working as tumor suppressor genes.For better understanding the relationship between miRNAs and liver diseases and the prospects for therapy in future,this review summarizes the effects of miRNAs on hepatitis,alcohol-induced liver injury and hepatocellular carcinoma.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2012年第9期793-796,共4页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金项目(No.30970353)~~
关键词
MIRNA
肝炎
酒精肝损伤
肝癌
miRNA
hepatitis
alcohol-induced liver injury
hepatocellular carcinoma
