摘要
目的:探讨胰腺衍生因子(PANDER)在前列腺癌(PCa)中的表达及其意义。方法:应用免疫组织化学SP法检测48例PCa组织和24例BPH组织标本的PANDER表达。结果:PANDER蛋白在前列腺(癌)上皮细胞中表达,在PCa组织中的阳性表达率为31.25%,在BPH组织中的阳性表达率为83.33%。PCa组织中PANDER阳性表达明显低于BPH组织,差异有统计学意义(P<0.001)。PANDER在PCa的Gleason分级为高分化组、中分化组和低分化组中的阳性表达率分别为57.14%、38.89%和17.39%(P<0.05)。结论:PANDER在PCa发生、发展、浸润的过程中可能发挥了一定作用。
Objective： To investigate the expression of Pancreatic-Derived Factor（PANDER） protein and its significance in prostate cancer. Methods： The expressions of PANDER protein was detected in 48 cases of prostate cancer and 24 cases of benign prostate hyperplasia（BPH）by immunohistochemistry. Results： The PANDER protein was expressed in prostate endothelial cell. The positive expression rate of PANDER was 31.25% in prostate cancer, significantly lower than 83.33% in BPH （P〈0. 001）. Statistically significant difference was found. The positive expression rate of PANDER among different Gleason grades, 57.14% in well differentiated, 38.89% in moderately differentiated, and 17.39% in lowly differentiated prostate cancer （P〈0.05）. Conclusions： The PANDER protein may play a certain role in the development, progression and infihration of prostate cancer.
出处
《临床泌尿外科杂志》
2012年第9期654-656,共3页
Journal of Clinical Urology
基金
海南省自然科学基金资助项目(编号808164)
