摘要
目的研究瑞芬太尼不同用药顺序对罗库溴铵起效时间的影响。方法 68例择期全麻病人随机分成两组,Ⅰ组麻醉诱导注药顺序为瑞芬太尼、丙泊酚、罗库溴铵,Ⅱ组麻醉诱导注药顺序为丙泊酚、罗库溴铵、瑞芬太尼。观察罗库溴铵的起效时间,记录诱导前、罗库溴铵注药毕、插管前及插管后即时平均动脉压和心率。结果与Ⅱ组比,Ⅰ组罗库溴铵起效时间明显延长;罗库溴铵注药毕即时平均动脉压和心率明显降低(P<0.01)。结论不同瑞芬太尼用药时机会影响罗库溴铵的起效时间。
Objective： To evaluate the effects of different drug-administration sequence of remifentanil on the onset time of rocuronium.Methods： Sixty-eight patients were randomly divided into two groups acording to drug-administration sequence of remifentanil.In Group Ⅰ（n=34）,remifentanil was infused first,followed by propofol.Then,rocuronium was administered lastly.In Group Ⅱ（n=34）,propofol,rocuronium,and remifentan-il were given in that order.the onset time of rocuronium was measured.Mean arterial pressure（MAP）,heart rate（HR）,were recorded before anesthesia（T1）,at injection of rocuronium（T2）,immediately before and after intubation（T3 and T4）.Results： In GroupⅠ,the onset of rocuronium was delayed significantly compared with Group Ⅱ [129（104-144） vs.94（72-102） s,P0.001].At the time of rocuronium injection（T2）,MAP,HR was significantly lower in GroupⅠ than that in Group Ⅱ（P〈0.01）.Conclusion： The onset time of rocuronium is prolonged significantly by early administration of remifentanil.
出处
《泰山医学院学报》
CAS
2012年第5期356-357,共2页
Journal of Taishan Medical College
