摘要
应用 Platt法切除 SD大鼠大部肾脏 ,通过血生化及骨矿化物的观察 ,发现其能诱发慢性肾功能衰竭。随着肾衰的加重 ,动物出现高磷低钙血症 ,高甲状旁腺激素 (PTH)血症以及骨矿化物含量下降等肾性骨病的表现。这提示该模型颇似人类慢性肾衰的表现 。
By observing biochemical markers and bone minerals content,it was found that subtotal nephrectomized rats by Platt’s method could give rise to chronic renal failure (CRF). Moreover, as renal failure was deteriorating, bone disease began to appeared. Hyperparathyroidism, hyperphosphatamia, hypocalcemia. and degradation of bone mineralization were occurred. It was demonstrated that the model could imitate the manifestations of secondary bone disease in human with CRF. The model is useful for the screening of effective medicine for the treatmont of chronic renal failure and secondary hyperparathroidism and bone disease.
出处
《上海实验动物科学》
2000年第1期11-13,共3页
Shanghai Laboratory Animal Science
基金
上海市卫生局"百人计划"经费资助!(编号:97BR043)
