摘要
目的 观察精纯抗栓酶治疗急性脑梗死的临床疗效。 方法 1 56例经临床和头颅 CT确诊的急性脑梗死患者 ,随机分为治疗组 (80例 )和对照组 (76例 )。对照组应用低分子右旋糖酐 50 0 ml加复方丹参 2 0 ml静滴 ,每天 1次 ,连用 1 4天。治疗组在对照组治疗基础上 ,辅予应用精纯抗栓酶。两组均于治疗前后观察血液流变学、血小板计数及出、凝血时间。并于治疗前和治疗后 2 1天作神经功能评分 ,结合治疗后患者病残程度评定疗效。 结果 治疗组有效率 88.8% ,明显高于对照组 68.4 % (P <0 .0 1 ) ,治疗组治疗后纤维蛋白原下降明显 (P <0 .0 0 1 ) ,部分患者凝血时间延长 ,对出血时间及血小板无明显影响。 结论 精纯抗栓酶能有效地降低纤维蛋白原 ,降低血粘度促进纤溶过程 ,是急性脑梗死早期治疗安全。
Objective To observe the clinical effect of pure antithrombine in treatment of cerebral infarction Methods 156 patients who were confirmed to have cerebral infarction through CT were divided into the treatment group(80) and the control(46) at randomThe control were given intravenous drips of dextran 500ml plus compound ginseng extract,once daily for 14 daysThe treatment group receiving the same dosage as the control,were given pure anticthrombinBefore the treatment,the records of blood rheology,platelet counts and time taken for bleeding and coagulation of both groups were keptThe nerve functions of both groups and their aftereffects were also evaluated after three weeks Results Clinical effect of the treatment group was 888% was much high,comparing to 684% of the control(P<001) After the treatment,the treatment group showed lower fibrinogen(P<0001) and some of the patients had longer time for coagulation,no difference in platelet count and time for bleedingConclusion Pure antithrombin is an effective and safe medicine for acute cerebral infarction because it can efficiently lower fibrinogen and reduce blood viscosity
出处
《蛇志》
2000年第2期14-15,共2页
Journal of Snake
关键词
精纯抗栓酶
急性脑梗死
药物治疗
疗效试验
pure antithrombine,acute cerebral infarction,clinical observation
