摘要
目的:探讨硬膜外麻醉与全凭静脉麻醉对中老年患者认知功能的影响。方法:120例中老年手术患者随机分为硬膜外麻组和全麻组各60例,分别采用硬膜外阻滞麻醉和全凭静脉麻醉,术前、术后采用MMSE评分对患者认知功能进行评价。结果:两组患者无一中止研究,两组手术血压、出血量、麻醉时间、手术时间之间差异无统计学意义(P>0.05)。两组术前1天MMSE评分差异无统计学意义(P>0.05),硬膜外麻组术后3h、6h、24hMMSE评分均显著低于基线得分,差异有统计学意义(P<0.05),术后72hMMSE评分基本恢复,全麻组术后各时段MMSE均显著低于基线得分(P<0.05),术后3h、6h、24h、72h硬膜外麻醉组得分均显著高于全麻组(P<0.05)。术后3h、6h、24h和72h硬膜外麻组POCD发生率均显著低于全麻组(P<0.05)。结论:中老年手术患者采用硬膜外麻醉效果良好,对认知功能的影响小,可减少POCD的发生。
Objective：To investigate the epidural anesthesia and total intravenous anesthesia in elderly patients with cognitive function.Methods：120 cases of elderly surgical patients were randomly divided into 60 cases of epidural anesthesia group and the general anesthesia group,respectively,the use of epidural anesthesia and total intravenous anesthesia,preoperative and postoperative MMSE score of patients with cognitive function evaluation.Results：There were a suspension of study,two groups of surgical blood pressure,bleeding,anesthesia time,operative time,the difference was not statistically significant（P〈0.05）.No significant MMSE score differences in both groups before and 1 day（P〈0.05）,epidural anesthesia group after 3h,6h,24hMMSE ratings were significantly lower than the baseline score,the difference was statistically significant（P〈0.05）.Score of postoperative 72hMMSE basic recovery,the anesthesia group at various time intervals after MMSE were significantly lower than baseline scores（P〈0.05）,postoperative 3h,6h,24h,72h epidural anesthesia group scored significantly higher than the general anesthesia group（P〈0.05）.Postoperative 3h,6h,24h and 72h epidural anesthesia group POCD incidence were significantly lower than the general anesthesia group（P〈0.05）.Conclusion：In elderly patients undergoing epidural anesthesia can reduce the occurrence of POCD of little influence on cognitive function.
出处
《中国医药导刊》
2012年第8期1343-1344,共2页
Chinese Journal of Medicinal Guide
