摘要
目的研究重型肝炎患者血清学指标与预后的相关性,并建立预后判断模型。方法收集145例重型肝炎患者的血清学指标,运用非条件Logistic回归模型分析这些因素与预后的关系。结果 145名患者中好转54例,死亡91例,病死率62.8%(91/145)。多因素回归模型分析结果显示,进入回归方程的因素有:凝血酶原活动度、血清钠、肌酐、血氨。回归模型为:P=1/(1+e-y),Y=-4.409-0.088×PTA-0.141×Na++0.016×Cr+0.023×血氨。结论凝血酶原活动度、血清钠、肌酐、血氨是判断重型肝炎预后的主要危险影响因素。
Objective To study the relation between serological indicators and prognosis, and develop a prognosis predicting model for patients with severe hepatitis. Methods Laboratory parameters were collected from 145 cases of severe hepatitis. The relation between factors and prognosis of severe hepatitis was explored by logistic regression analysis. Results Among the 145 patients,54 cases recovered and 91 cases dead, the case fatality rate was 62.8% （91/145）. Logistic regression analysis showed that the factors associated with prognosis of severe hepatitis were ： prothrombin activity, sodium, creatinine, ammonia. The prognosis predicting model was P = 1/（ 1 ＋ e^-y）, y = -4.409 -0.088 × PTA- 0. 141 ×Na ^＋ ＋ 0.016 × Cr ＋ 0. 023 × ammonia. Conclusion Prothrombin activity, sodium, ereatinine, ammonia are the main risk factors related to prognosis of severe hepatitis.
出处
《中华全科医学》
2012年第10期1520-1521,共2页
Chinese Journal of General Practice
