摘要
目的:观察天麻钩藤降压胶囊降压及镇静安神的作用。方法:SHR大鼠以天麻钩藤降压胶囊(5.4,10.8,21.6 g.kg-1)ig,1次/d,连续给药4周,观察对大鼠收缩压的影响;小鼠以天麻钩藤降压胶囊(7.8,15.6,31.2 g.kg-1)ig,1次/d,连续5 d,末次给药1 h后,ip戊巴比妥钠55 mg.kg-1,记录睡眠时间;ip硫代氨基脲16 mg.kg-1,记录惊厥时间(惊厥潜伏期),惊厥次数;末次给药1 h后,将动物放入YLS-1A多功能小鼠自主活动记录仪,记录10 min内小鼠自主活动次数。结果:天麻钩藤降压胶囊低、中、高剂量给药均可明显降低SHR大鼠收缩压(P<0.01);天麻钩藤降压胶囊高剂量组能明显延长戊巴比妥钠致小鼠睡眠时间,模型组和高剂量组分别为(42.70±12.23),(91.40±64.79)min,(P<0.05),高剂量组延长硫代氨基脲所致小鼠惊厥潜伏期,模型组与高剂量组分别为(56.20±7.69),(68.70±19.34)min,(P<0.05),对惊厥次数无显著影响;天麻钩藤降压胶囊对小鼠自主活动无明显影响。结论:天麻钩藤降压胶囊有一定的降压和镇静催眠作用。
Objective： To observe the anti-hypertentive and sedative effects of Tianma Gouteng Jiangya capsules （TGJC）. Method： Spontaneous hypertention rats were orally given TGJC （5.4, 10. 8, 21.6 g .kg-1） daily for4 weeks. Anti-hypertentive effect was evaluated. Mice were orally given TGJC （7.8, 15.6, 31.2 g. kg-1） daily for 5 days. One hour after the last administration, intraperitoneal injection of sodium pentobarbital 55 mg .kg-1 was carried out, and sleep time was recorded. Similarly, intraperitoneal injection of thio-semicarbazide （16 mg .kg-1） was carried out, the time of convulsions and the incubation period were recorded. In addition, one hour after the last administration, mice were placed in YLS-1A versatile recorder to record the number of locomotor activities in mice within 10 rain. Result： Three doses of TGJC could significantly reduce the blood pressure in the hypertensive rats （P 〈0.01 ）. TGJC high dose could significantly prolong the sodium pentobarbital induced sleep time P 〈 0.05 ） , extend the thio-semicarbazide-induced seizure latency （ P 〈 0.05 ） , without significant effect on the number of seizures. TGJC had no effect on locomotor activity in mice. Conclusion： TGJC has some antihypertention and sedative effects.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第17期241-243,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
天麻钩藤胶囊
催眠
镇静
自主活动
Tianma Gouteng Jiangya capsule
hypnotic
sedative
locomotor activity
