摘要
免疫球蛋白样转录物(immunoglobulin-like transcript,ILT)家族表达于髓系和淋系细胞表面,功能上可分为抑制性或激活性受体两大类,通过与相应的配体结合诱导免疫抑制或免疫应答作用。ILT2/4受体通过与其配体人类白细胞抗原-G(human leukocyte antigen-G,HLA-G)相互作用,传递抑制信号,调节免疫活性细胞的生物学功能或诱导耐受型DC细胞(tolerogenic dendritic cells,tDC)/调节性T细胞(regulatory T cells,Treg)/髓系衍生抑制性细胞(myeloid-derived suppressor cells,MDSCs)的产生。就ILTs受体在HLA-G免疫耐受机制中的研究进展作一综述。
The immunolglobulin-like transcript （liT） family of proteins are surface receptors expressed by myeloid and lymphoid ceils, including inhibitory receptors and activated receptors. Its interaction with corresponding ligands could induce immunosuppression or immune activation in various condictions. The interaction of the ligand human leukocyte antigen-G and ILT2/4 promotes immune suppressive activity and induces tolerogenic dendritic cells and regulatory T cells or myeloid-derived suppressor cells （MDSCs）. Here we discuss the recent studies on the roles of immunolglobulin-like transcript family receptors in tolerogenic immune regulation with their interaction with HLA-G.
出处
《生命科学》
CSCD
2012年第7期640-645,共6页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31170879
81102218)
