摘要
目的探讨细胞黏附分子钙黏蛋白(E-cad)、层粘连蛋白(LN)、Ⅳ型胶原蛋白(ColⅣ)和增殖细胞核抗原(PCNA)表达与乳腺癌的关系。方法采用免疫组织化学技术对80例乳腺癌E-cad、LN、ColⅣ和PCNA的表达进行检测。结果 E-cad低表达率与乳腺癌组织类型、分化程度、临床分期、转移及生存期短显著相关(P<0.01);基底膜缺损程度在分化低、临床Ⅲ～Ⅳ期、有转移及生存期<5年的乳腺癌组,显著高于分化高、临床Ⅰ～Ⅱ期、无转移及生存期≥5年组(P<0.01),而PCNA的表达在前组中显著增高(P<0.01)。结论 E-cad、LN、ColⅣ和PCNA的表达可作为临床判断乳腺癌浸润转移及预后的重要指标。
Objective To discuss the relationship between the expressions of E-cadherin （E-cad）, laminin（LN）, collagen IV （CollV）, proliferating cell nuclear antigen （PCNA） and the prognosis of the breast cancer. Methods The expressions of Ecad, LN, Coliv and PCNA in 80 cases of breast cancer were measured by immunohistochemical technique. Results There was a significant difference between the low expressive rate of E-cad, and histologic types, differential grades, clinical stages, metastasis and short survival periods in breast cancer （P 〈 0.01）; there were many more defects in the basic membrance of breast cancer for the poor differential grades, stages Ⅲ-Ⅳ, metastases and survival time 〈 5 years than that for the high differential grades, stages Ⅰ- Ⅱ, no metastases and survival time ≥ 5 years （P 〈 0.01）, on the other hand, signifi- cant increases of PCNA expression were showed in the former ones （P 〈 0.01）. Conclusion The expressions of E-cad, LN, ColⅣ and PCNA in breast cancer can be used as important indicates for the judgements of infiltration, spread and prognosis of breast cancer.
出处
《中国当代医药》
2012年第23期146-147,149,共3页
China Modern Medicine
