摘要
目的探讨PET／CT定位对后程加速超分割三维适形放射治疗Ⅲ期肺鳞癌患者疗效的影响。方法将79例行放射治疗的Ⅲ期肺鳞癌患者，根据病灶定位方式的不同将所有患者分为PET／CT组（PET／CT定位）37例和普通CT组（普通CT定位）42例，前2／3疗程结果常规超分割三维适形放射治疗治疗（40Gy左右），后1／3采用加速超分割三维适形放射治疗（1．5Gy左右，2次／d）；两组患者均采用相同的化疗方案辅助治疗。全疗程1个月左右。观察两组临床疗效和治疗过程中出现的各种不良反应等。结果PET／CT组和普通CT组总缓解率分别为73．0％和71．4％（x2=1．347，P〉0．05）；两组患者发生的放射损伤主要包括肺和气管损伤，急性期两组的发生率分别为56．8％和57．1％，差异无统计学意义（X2=2．178，P〉0．05），晚期普通CT组放射损伤的发生率为69．0％，显著高于PET／CT组62．2％（x2=4．142，P〈0．05）。随访1年PET／CT组患者肺门和纵隔淋巴结复发率为43．7％，显著低于普通cT组的59．4％（X2=4．732，P〈0．05）。结论PET／CT定位对后程加速超分割三维适形放射治疗Ⅲ期肺鳞癌患者可以减少晚期肺和气管损伤，降低肺门和纵隔淋巴结复发率。
Objective To investigate the influence of PET/CT positioning on the effect of late-course accel- erated hyperfractionated and three-dimensional conibrmal radiotherapy for stage Ⅲ lung squamous cell carcinoma. Methods 79 stage Ⅲ lung squamous cell carcinoma patients were enrolled and divided into PET/CT group （n = 37 cases, PET/CT positioning） and general CT group （n = 42 cases, general CT positioning） according to the way of posi- tioning. The conventional fractionated 3 DCRT（ about 40 Gy） was used in previous 2/3 time and hyperfractionated（ a- bout 1.5 Gy） was used in later 1/3 time. Both groups used chemotherapy as adjuvant therapy. Full course of the treatment was a month or so. And the clinical efficacy and a variety of adverse reactions of the two groups was observed. Results The total rate of remission in PET/CT group were 73.0% , and 71.4% in general CT group, and there was no significant difference in the two groups（ X2 = 1. 347 ,P 〉 0.05 ）. The major radiation injury were radioactive pulmo- nary injury and tracheal damage, incidence rates were 56.8% and 57.1% in acute stage, and there was no significant difference in the two groups（ X2 = 2. 178, P 〉 0.05 ） ;but in late stage 69.0% in general CT group was significantly higher than 62.2% in PET/CT group（ X2 = 4. 142 ,P 〈 0.05 ）. After followed-up 1 year, the recurrence rate of hillar and mediastinal lymph node in PET/CT group was 43.7% ,lower than that of the general CT group（59.4% ） （X2 = 4. 732, P 〈 0.05 ）. Conclusion PET/CT positioning in late-course accelerated hyperfractionated and three-dimen- sional conformal radiotherapy for stage m lung squamous cell carcinoma could reduce late stage radioactive pulmonary injury and tracheal damage,lower the recurrence rate of hillar and mediastinal lymph node.
出处
《中国基层医药》
CAS
2012年第17期2590-2591,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
体层摄影术
X线计算机
正电子发射型
后程加速放疗
肺肿瘤
Tomography ,X-ray
Positron emission
Late-course accelerated fractionated radiotherapy
Lung carcinoma
