摘要
目的 评价 0 5 %环孢霉素A (cyclosporinA ,CSA)滴眼剂对干眼症患者泪液的影响。方法 6 0例 (6 0只眼 )干眼症患者被随机分为CSA组 (30例 )和对照组 (30例 )。CSA组应用 0 5 %CSA滴眼剂滴眼每日 4次 ,连续治疗 1个月。对照组应用人工泪液滴眼每日 4次 ,连续治疗 1个月。两组治疗前进行视力、眼表裂隙灯检查、荧光素染色检查、Schirmer-1试验、泪膜破裂时间 (BUT)检测、泪膜镜检查泪膜形态等级。用药 1个月后复查比较。结果 CSA组与人工泪液组治疗前Schirmer -1、BUT、角膜荧光素染色、泪膜镜检查分级经t检验差异无显著性(P >0 0 5 ) ,治疗后Schirmer-1试验和BUT检测经t检验差异有显著性 (P <0 0 5 )。两组治疗前后角膜荧光素染色、泪膜镜检查等级经 χ2 检验差异有显著性 (P <0 0 1 ) ,结论 0 5
OBJECTIVE To investigate the effect of 0 5% cyclosporin A(CSA) on tears of the patients with ophthalmoxerosis. METHODS Sixty patients with ophthalmoxerosis were divvied into CSA group(30 cases ) and artificial tears group (30 cases) randomly. Their ophthalmoxerosis were treated with 0 5% CSA in the CSA group and with artificial tears in the control group both 4 times each day, and the patients had been treated for one month in two groups. Test of visual acuity, segment slit-lamp examination, stain of cornea by fluorescein. Schirmer-Ⅰ test , breakup time of tear film , and examinations of the morphology and grading of the tear films were performed in two groups before the treatment. These tests and examinations were repeated at one month after treatment. RESULTS Before the observation difference were not statistic significant between two groups by t-test in Schirmer-Ⅰ test , breakup time of tear film, stain of cornea by fluorescein, and examinations of the morphology and grading of the tear films ( P >0 05),and difference of Schirmer-Ⅰ test , breakup time of tear film was statistic significance by t-test between two groups( P <0 05). After treatment data of the fluorescein stain of cornea and the grading of the tear films were obviously better and the difference was statistics significant both groups than pretreatment( P <0 01)by χ 2 test. CONCLUSION 0 5% CSA is effect obviously on treatment of ophthalmoxerosis
出处
《中国中医眼科杂志》
2000年第3期136-139,共4页
China Journal of Chinese Ophthalmology
