摘要
目的:探讨天灸治疗阳虚寒凝型膝骨性关节炎的临床疗效。方法:选择2010年7-8月福建中医药大学附属第二人民医院门诊78例阳虚寒凝型膝骨性关节炎患者,抽签法随机分为治疗组40例(53例膝),采用天灸治疗;对照组38例(50例膝),采用奥泰灵治疗。观察2组治疗前后临床疗效、症状积分变化;并测定治疗前后关节滑液中C-反应蛋白(C-RP)、透明质酸(HA)、白介素-1(IL-1)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及基质金属蛋白酶-3(MMP-3)含量。结果:收集78例(103例膝),完成治疗75例(99例膝),其中,治疗组脱落病例2例(2例膝),对照组脱落病例1例(2例膝)。2组治疗后,治疗组有效率为90.20%,对照组有效率为85.42%,治疗组优于对照组(P<0.05);2组均能改善患者临床症状积分,并有效降低关节滑液中C-RP、IL-1、IL-6、TNF-α及MMP-3的含量(P<0.05)。其中,治疗组在改善患者临床症状积分、降低IL-1、IL-6、TNF-α含量方面优于对照组(P<0.05)。结论:天灸对阳虚寒凝型膝骨性关节炎患者有更好的临床疗效。
Objective：To investigate the effect of crude herb moxibustion on knee osteoarthritis（KOA） with Yang deficiency and cold coagulation syndrome.Methods：78 KOA patients with Yang deficiency and cold coagulation syndrome were selected from the outpatients of the Second affiliated hospital of Fujian university of TCM from July 2010 to August 2010,and assigned randomly to two groups.The treatment group（n=40） received crude herb moxibustion and the control group（n=38） were taken Glucosamine hydrochloride capsules.The curative effects and cumulative scores of symptoms of two groups before and after the treatment were observed and the changes of contents of synovial fluid C-RP,HA,IL-1,IL-6,TNF-α and MMP-3 were determined.Results：75 patients completed the treatment.After the treatment,the effective rate in the treatment group and the control group was 90.20%,85.42%respectively,and the difference was statistically significant between the two groups（P〈0.05）.The cumulative scores of symptoms and the contents of C-RP,IL-1,IL-6,TNF-α and MMP-3 were significantly decreased after treatment in both groups（P〈0.05）.In the aspect of improving symptoms,reducing the contents of IL-1,IL-6 and TNF-α,the treatment group is superior to the control one（P〈0.05）.Conclusion：Crude herb moxibustion has good curative effect for KOA with Yang deficiency and cold coagulation syndrome.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第8期2227-2230,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金(No.30873277)
陈可冀中西医结合发展基金(No.CKJ2008003)~~
关键词
骨性关节炎
天灸
阳虚寒凝型
临床研究
Osteoarthritis
Crude herb moxibustion
Yang deficiency and cold coagulation syndrome
Clinical research
