摘要
氟硼吡咯和氮杂氟硼吡咯分别与草酰氯在N,N-二甲基甲酰胺溶液中发生Vilsmeier-Haack反应,生成相应的β-甲酰氟硼吡咯和β-甲酰氮杂氟硼吡咯.该反应分别在室温和50℃搅拌条件下顺利实现,并对氟硼吡咯和氮杂氟硼吡咯两种底物都具有较高产率.此外,该反应具有原料易得、低污染的优点.
A series of β-formyl-boron-dipyrromethenes（BODIPYs） 2 and β-formyl-aza-BODIPYs 4 were synthesized from tetramethyl-BODIPYs 1 and tetraaryl-aza-BODIPYs 3 respectively via the Vilsmeier-Haack reaction using（COCl）2and DMF as the precursors efficiently.The Vilsmeier-Haack reaction was carried out smoothly under room temperature or 50 ℃ for BODIPYs or aza-BODIPYs respectively to give the β-formyl products in good yield.The advantage of this new method is the using of commercially available chemical and the less pollution.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第8期1503-1508,共6页
Chinese Journal of Organic Chemistry
