摘要
目的观察无抽搐电休克(MECT)合并艾司西酞普兰治疗难治性抑郁症的综合疗效及不良反应。方法将符合入组标准的68例患者随机分为MECT合并艾司西酞普兰组(研究组)和单用艾司西酞普兰组(对照组),共观察8周,分别于治疗前和治疗第1、2、4、8周末采用汉密尔顿抑郁量表17项(HAMD-17)、汉密尔顿焦虑量表(HAMA)和临床疗效总评量表(CGI)评定临床疗效,副反应量表(TESS)评定不良反应。结果治疗后两组HAMD、HAMA评分较治疗前均有显著性降低(均P<0.01),治疗第1、2、4、8周末,研究组的HAMD及HAMA评分显著低于对照组(P<0.05或P<0.01),治疗第8周末研究组CGI评分显著低于对照组(P<0.05)。两组不良反应均较少,差异无统计学意义(P>0.05)。结论 MECT合并艾司西酞普兰治疗难治性抑郁症疗效确切,起效快,安全性好,优于单用艾司西酞普兰。
Objective To explore the efficiency and adverse reaction of modified electroconvulsive therapy （MECT） combined with escitalopram in the treatment of refractory depression. Methods A total of 68 patients with refractory depression were randomized into study group treated with MECT combined with escitalopram and control group treated with escitalopram monotherapy for 8 weeks. All patients were assessed with 17-item Hamilton Depressive Scale （ HAMD -17）, Hamilton Anxiety Scale （HAMA）, Clinical Global Impression Scale （CGI） at baseline and at the 1st, 2nd, 4th, 8th weekend to evaluate the efficiency. Treatment Emergent Symptom Scale （TESS） was used to evaluate the adverse reactions. Results Compared with baseline, scores of HAMD, HAMA in the two groups decreased significantly （P 〈0.01）. Scores of HAMD, HAMA in study group were significantly lower than those in control group at the 1st, 2nd, 4th, 8th weekend of the treatment （P 〈0.05 or P 〈0.01 ）. Score of CGI in study group was significantly lower than that in control group at the end of the treatment （ P 〈 0.05 ）. Adverse reactions in the two groups were mild and there was no significant difference in adverse reactions between the two groups （P 〉 0.05 ）. Conclusion Compared with escitalopram monotherapy, MECT combined with escitalopram has better efficiency and takes effect more quickly in the treatment of refractory depression.
出处
《精神医学杂志》
2012年第4期280-282,共3页
Journal of Psychiatry
