摘要
目的 探讨慢性阻塞性肺疾病（COPD）患者血清中内皮素-1（ET-1）、肿瘤坏死因子α（TNF-α）和细胞黏附分子-1（ICAM-1）水平变化及其临床意义。方法 选择80例COPD患者（其中急性加重期47例、缓解期33例）作为观察对象,以30例健康体检者作为对照,采用酶联免疫法（ELISA）检测血清中ET-1、TNF-α和ICAM-1水平,并分组比较。结果 COPD患者血清ET-1、TNF-α和ICAM-1水平明显高于对照组（t=4.896、4.621、4.231,均P＜0.05）,COPD急性加重期ET-1、TNF-α和ICAM-1水平明显高于缓解期（t=3.346、3.525、3.269,均P＜0.05）。结论 ET-1、TNF-α和ICAM-1共同参与了COPD的发病机制,在气道炎性反应中起着重要作用。
Objective To investigate the clinical significance of Endothelin-1,Tumor necrosis factor-α and Intercellular adhesion molecule-1 in the patients with chronic obstructive pulmonary disease（COPD）.Methods The serum samples were prepared from 80 cases with COPD and 30 healthy persons.The levels of ET-1,TNF-α and ICAM-1 were measured by enzyme-linked immunosorbent assay（ELISA）.Results Levels of ET-1,TNF-α and ICAM-1 in the COPD patients were higher than thosein the healthy cases（t=4.896,4.621,4.231,all P＜0.05）.Levels of ET-1,TNF-α and ICAM-1 in the period of AECOPD were higher than those in the cases of the COPD stable time（t=3.346,3.525,3.269,all P＜0.05）.Conclusion ET-1,TNF-α and ICAM-1 are involved in airway inflammation,ET-1,TNF-α and ICAM-1 not only take part in the acute inflammation in COPD,but also closely connected with clinic stages.
出处
《中国基层医药》
CAS
2012年第16期2429-2430,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肺疾病
慢性阻塞性
内皮素-1
肿瘤坏死因子Α
细胞黏附分子-1
Pulmonary disease,chronic obstructive
Endothelin-1
Tumor necrosis factor-α
Intercellular adhesion molecule-1
