摘要
目的探讨5′-核苷酸酶(5′-NT)评价乙型肝炎(简称乙肝)患者肝功能的作用。方法检测健康体检者30例(对照组)、乙肝大三阳[指乙肝表面抗原(HBsAg)、乙肝e抗原(HBeAg)、乙肝核心抗体(抗-HBc)均阳性]患者50例(大三阳组)和小三阳(指HBsAg、抗-HBe、抗-HBc均阳性)患者20例(小三阳组)血清中5′-NT、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、γ-谷氨酰转移酶(GGT)水平,并进行t检验。结果大三阳组患者血清5′-NT、ALT、AST、TBIL、GGT水平较对照组、小三阳组明显升高,差异有统计学意义(P<0.05)。小三阳组患者ALT、AST、GGT水平较对照组升高,差异有统计学意义(P<0.05),但5′-NT、TBIL水平与对照组比较,差异无统计学意义(P>0.05)。结论 5′-NT对乙肝患者的肝功能评价具有特异性,与其他肝功能指标协同测定可作为乙肝患者判断病情严重程度及观察治疗效果的指标。
Objective To investigate the role of 5＇-nucleotidase （5＇-NT） for evaluating the liver function in hepatitis B patients. Methods 5＇-NT, ALT, AST, TBIL and GGT were detected in 30 healthy persons （control group）, 50 hepatitis B patients with HBsAg, HBeAg, and HBcAb test positive and 20 hepatitis B patients with HBsAg, HBeAb, and HBcAb test positive. The t- test was performed. Results The values of 5＇-NT, ALT, AST, TBIL and GGT were increased in the HBsAg,HBeAg,and HBcAb positive group than that of the control group and the HBsAg, HBeAb, and HBcAb positive group, showing statistical difference among them （P〈0.05）. The values of ALT, AST and GGT were increased in the HBsAg, HBeAb, and HBcAb positive group than the control group with statistical difference （P〈0.05）. But the values of 5＇-NT and TBIL in HBsAg, HBeAb, and HBcAb pos- itive groupshowed nostatistical difference compred with the control group（P〉0.05 ）. Conclusion 5＇-NT has the specificity for e valuating the liver function in hepatitis B patients, its combination detection with other indexes of liver function can be used as the index for evaluating the severity degree of disease condition and observing the curative effects.
出处
《现代医药卫生》
2012年第15期2243-2243,2245,共2页
Journal of Modern Medicine & Health
基金
泸州医学院青年基金课题(泸医院〔2012〕108号)
