摘要
目的:对中西医结合疗法及西医疗治疗皮肌炎的临床疗效及对肿瘤坏死因子-α(TNF-α)的影响进行研究分析,证实中西医结合疗法在治疗皮肌炎中的确切疗效。方法:以2008年8月—2011年12月我院治疗的78例皮肌炎患者为研究对象,将其随机分为两组。一组患者52例,使用中西医结合疗法进行治疗,为观察组;一组患者26例单纯使用西医疗法进行治疗,为对照组。治疗一定周期后,对两组患者的肌酸磷酸激酶、细胞沉降率及对TNF-α的影响等临床数据进行比较,并进行统计学分析。结果:治疗后观察组患者的肌酸磷酸激酶(CPK)和细胞沉降率(ESR)分别为(381.5±85.8)U.L-1和(18.8±13.7)mm.h-1,较对照组有显著优势。两组患者治疗后不良反应等临床数据均P<0.05;治疗前后肌酸磷酸激酶和细胞沉降率及TNF-α的比较中,治疗后均较治疗前有明显改善,经统计学分析,具有显著统计学差异(P<0.05);对两组患者治疗前后的TNF-α变化情况进行比较,观察组ΔTNF-α为(0.52±0.17)mg.L-1,较对照组ΔTNF-α的(0.34±0.09)mg.L-1有明显优势,经统计学分析P<0.05。结论:在皮肌炎的治疗中中西医结合疗法较西医疗法具有疗效显著,对TNF-α的影响明显等优势,适于临床推广使用。
Objective： To combine traditional Chinese and western medicine and western medical treatment of dermatomyositis clinical curative effect and the influence to tumor necrosis factor-or （TNF-α） to carry on the research analysis, confirmed by integrated traditional Chinese and western medicine therapy in the treatment of dermatomyositis in exact curative effect. Method： In 2008 August-2011 December in our hospital treatmen,t of 78 cases of patients with dermatomyositis as the research object, divide them into two groups. A group of 52 patients, using a combination of traditional Chinese and western medicine therapy, observation group; a group of patients with 26 cases of using western medicine therapy, as compared to a control group. Treatment after a certain period, the clinical efficacy of the two groups and the influence to TNF-α were compared, and carries on statistics analysis. Result： Creatine phosphokinase （CPK） and erythrayte sedimentation rate （ESR） and adverse reaction of curative effect index all relatively contrast group have obvious advantages, through statistical analysis, with a significant difference （ P 〈 0.05） in TNF-α; comparison of the effect of observation group than in the control group, the patients have obvious advantages, through statistical analysis, with a significant difference （P 〈 0. 05）. Conclusion： In dermatomyositis therapy in combined treatment of TCM and western medicine than western medicine therapy has obvious curative effect, the influence to TNF-α and other advantages, is suitable for clinical use.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第16期317-319,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
皮肌炎
中西医结合
疗效
肿瘤坏死因子-Α
dermatomyositis
combination of traditional Chinese and western medicine
curative effect
tumor necrosis factor-α
