摘要
MiRNA是真核生物体内约由22个核苷酸组成的内源性非编码单链RNA,可调节基因转录。它通过其5'非翻译区(UTR)与目标mRNA的3'端非翻译区相结合,从而抑制后者的转录后翻译和降解,进而调节一系列生物学过程,包括生物体生长、发育和疾病等。研究表明,miRNA在干细胞分化、肿瘤形成、血管发生、内耳形成等过程中均发挥重要作用,已成为调节生物学过程的核心因子。伤口愈合是一个与多种类型细胞、细胞因子及细胞外基质相关的过程,它受机体多种因素紧密调控。伤口愈合过程一般被分为三个阶段:炎症反应期,肉芽生长期和组织重建期。已有大量证据证实miRNA在皮肤创伤愈合过程中发挥重要作用,并且miRNA在不同的愈合阶段发挥不同的作用。本文就miRNA在皮肤形态、胎儿无痕愈合及成人伤口愈合各环节中的作用做一综述。
MiRNAs are ～22-nucleotide-long endogenously expressed non-coding single-strain RNAs that regulate the gene transcription.They could modulate the growth,development and diseases of organism by inhibition of post-transcriptional translation and degradation of mRNA,through binding its 5’ UTR to 3’UTR of mRNA.It has been proposed that miRNAs play a significant role in differentiation of stem cells,formation of cancer,angiogenesis,development of inner ear,and so on,which has been a core factor of regulation of biological processes.Cutaneous wound healing is a complex biologic process involved in several type of cells,cytokines and extracellular matrix,which is strictly regulated by lots of factors.It has been divided into 3 phases： inflammation,granulation proliferation and tissue reconstruction.A large number of evidence suggested that miRNAs play a significant role in this process,and specific miRNAs are expressed in specific phases.This article reviews the role of miRNA in skin morphogenesis,fetal scarless healing and different stage of adult wound repair.
出处
《现代生物医学进展》
CAS
2012年第20期3985-3987,共3页
Progress in Modern Biomedicine
基金
国家863计划军口部分(2009AA8030423A)
国家自然科学基金(31171118)
