摘要
目的比较布托啡诺、芬太尼、布托啡诺联合芬太尼用于术后患者自控静脉镇痛(PCIA)的临床效果.方法 60例ASAⅠ～Ⅱ级的腹部手术患者,随机均分为布托啡诺组(B组)、芬太尼组(F组)、布托啡诺联合芬太尼组(BF组),术毕按3种方案实行PCIA.记录并比较术后2、4、8、18、24、48 h的疼痛视觉模拟评分(VAS)、Ramsay镇静评分及不良反应.结果 3组患者均达到了良好的镇痛效果,但术后8 h、18 h、24 h,BF组的VAS评分明显低于B组(P<0.05).B组术后4、8、18、24 h的Ramsay镇静评分明显高于F组(P<0.05).B组头晕发生率高于F组(P<0.05);BF组呕吐发生率低于F组(P<0.05).结论布托啡诺联合芬太尼用于术后镇痛效果确切,不良反应少,是一种较理想的术后镇痛方法.
Objective To compare the analgesic effects of butorphanol, fentanyl and butorphanol combined with fentanyl for postoperative patient-controlled intravenous analgesia （PCIA）. Methods Sixty ASA class I or Ⅱ patients undergoing abdominal operations were randomly assigned into three groups with 20 cases each. The patients in group B received butorphanol （0.2mg/mL, in group F fentanyl （10 ug/mL） , and in group BF butorphanol （0.1 mg/mL） with fentanyl （5 ug/mL） for PCIA. The PCA model for all groups was set with background infusion 2 mL/h, bolus of lml with lock time 15 min. The visual analogue scale （VAS） analgesic score, Ramsay sedation score and side effects were recorded and compared among three groups at 2, 4, 8, 18, 24, 48 h after the operations. Results Adequate analgesia was achieved in all three groups. VAS score of group BF was significantly lower than that of group B at 8, 18, 24 h after the operation （P 〈 0.05）. Ramsay sedation score of group B was significantly higher than that of group F at 4, 8, 18, 24h after the operation （P 〈 0.05） The incidence of dizziness of group B was significantly higher than that of group F （P 〈 0.05） . The incidence of postoperative vomiting of group BF was significantly lower than that of group F （P 〈 0.05）. Conclusion Butorphanol combined with fentanyl for postoperative intravenous analgesia shows effective analgesia with fewer side effects, which is good mixture for PCIA.
出处
《昆明医学院学报》
2012年第6期109-112,共4页
Journal of Kunming Medical College
关键词
布托啡诺
芬太尼
术后镇痛
Butorphanol
Fentanyl
Postoperative analgesia
