摘要
目的比较普通肝素和低分子肝素对AECOPD合并肺动脉血栓栓塞抗凝治疗的安全性和有效性.方法选择26例AECOPD合并非大面积肺栓塞患者,根据抗凝治疗的不同,将其分为普通肝素组和低分子肝素组.比较2组患者治疗前后症状缓解情况、D-二聚体、血气分析、螺旋CT肺动脉造影的变化及不良反应.结果治疗后2组患者症状、血气分析均明显改善,缺损肺动脉支数明显减少.普通肝素组的有效率、病死率分别为77%,7%,低分子肝素组分别为85%,7%,2组间差异无统计学意义(P>0.05).不良反应发生率普通肝素组高于低分子肝素组.结论普通肝素和低分子肝素均为治疗AECOPD合并肺动脉血栓栓塞的有效抗凝药物,但低分子肝素较普通肝素更安全.
Objective To compare the efficacy and security of common heparin and Low-molecular- weight heparin in the treatment of acute exacerbations of chronic obstruction pulmonary disease complicated with pulmonary embolism. Methods The 26 patients with acute exacerbations of chronic obstruction pulmonary disease complicated with non-massive pulmonary embolism were divided into two groups based the different anticoagulated treatment： the group of common heparin and the group of Low- molecular- weight heparin. The symptoms, the results of blood gas analysis, the spiral computed tomography pulmonary angiography and the adverse reactions were compared between the two groups. Results There were great improvements of the symptoms, the results of blood gas analysis in the two groups after treatment. The branches of embolized pulmonary arteries were reduced greatly. The effective rate and mortality were respectively 77% and 7% in the group of unfractionated heparin. Those of the group of Low-molecular-weight heparin were 85% and 7% respectively. There were no statistically significant difference between the two groups. The adverse reactions were higher in the group of unfractionated heparin than those of the Low-molecular-weight heparin group. Conclusion The common heparin and the low-molecular- weight heparin are also effective in the treatment of acute exacerbations of chronic obstruction pulmonary disease complicated with pulmonary embolism, but the Low-molecular-weight heparin is much safer than the common hepann.
出处
《昆明医学院学报》
2012年第6期82-84,102,共4页
Journal of Kunming Medical College
基金
云南省科技厅-昆明医科大学联合专项基金资助项目(2009CD170)
关键词
慢性阻塞性肺疾病
肺栓塞
普通肝素
低分子肝素
不良反应
Acute exacerbations of chronic obstruction pulmonary disease
Pulmonary embolism
Commonheparin
Low-molecular-weight heparin
Adverse reaction
