摘要
目的探讨化疗对肺癌及乳腺患者细胞免疫功能的影响。方法采用双色流式细胞术分析15例肺癌及5例乳腺癌患者化疗前后外周血中T淋巴细胞亚群的变化。结果与正常组比较,化疗前后恶性肿瘤组抑制性T淋巴细胞(T_s)百分率升高,而辅助性T淋巴细胞(T_h)百分率降低,T辅助/T抑制(T_h/T_s)比值显著降低;与化疗未缓解组比较,化疗缓解组T_s百分率所占比例下降,而Th细胞百分率及T_h/T_s比值上升。结论肺癌及乳腺癌患者细胞免疫功能低下,化疗缓解后细胞免疫功能有所改善,但仍低于正常组。
Objective To investigate the influence of chemotherapy to the cellular immune function in patients with lung cancer and breast caner. Methods T lymphocyte subsets were detected by flow cytometry in the peripheral blood of lung cancer patients （n = 15） and breast cancer patients （n = 5）. Results Compared with the normal group, the patients with carcinoma showed a significant decrease in percentage of T helper cells and the ratio of T helper/suppressor ceils, but an increase in percentage of T suppressor cells; Compared with chemotherapy ineffectiveness, the chemotherapy remission showed a decrease in percentage of T suppressor cells but an increase in percentage of T helper cells and the ratio of T helper/suppressor cells. Conclusions Cancer patients have lower cellular immune function, their cellular immune function is improved after effective treatment, but still lower than the normal group.
出处
《临床医学工程》
2012年第8期1263-1264,共2页
Clinical Medicine & Engineering
基金
广州市科信局重大科技专项计划项目子项目"广州市临床检验技术标准化研究与推广应用"(项目编号:2010U1-E00681-2)
关键词
T淋巴细胞亚群
流式细胞术
化疗
T-lymphocytes subsets
Flow cytometry
Chemotherapy
