摘要
采用高效液相色谱法在手性柱上分离芳氧基苯氧基丙酸类除草剂中间体(±)-2-(4-羟基苯氧基)丙酸酯的对映体.实验结果表明,在三苯甲酸纤维素酯的手性柱上,以无水乙醇为流动相能较好地分离(±)-2-(4-羟基苯氧基)丙酸乙酯和甲酯,其分离因子α值分别为1.44和1.29;同时还发现在三苯甲酸纤维素酯的手性柱上2-取代芳氧基或芳基丙酸酯结构中的酯基团的大小对其对映体的分离有明显的影响,其中以乙基为最佳.并通过对照试验证实了2-(4-羟基苯氧基)丙酸乙酯的右旋体先流出,其左旋体后流出.
The separation of enantiomers of(±)2-(4- hydroxyphenoxy)propionates, the intermediates for aryloxyphenoxypropionate herbicides, has been achieved by high - performance liquid chromatography on a chiral column. The experimental results showed that the enantiomers of the ethyl ester and methyl ester of 2 -(4 - hydroxyphenoxy) propionic acid could be well separated on the tribenzoylcellulose (CTB) chiral column with ethanol as mobile phase. Their separation factors were 1.44 and 1.29 respectively. At the same time, it was found that the size of the ester group in the 2 - substituted aryloxy or aryl propionates obviously affected the separation efficiency of their enantiomers on the CTB chiral column. The separation of enanatiomers of the ethyl ester was most satisfactory . And , the order of elution has been proved that the (+ ) - configuration of ethyl 2 - (4 - hydroxyphenoxy)propionate was eluted before the ( - ) - configuration by comparsion experiment.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2000年第6期696-699,共4页
Acta Chimica Sinica
关键词
2-(4-羟基苯氧基)丙酸酯
映体分离
HPLC
(±)2 - (4- hydroxyphenoxy)propionate, chiral stationary phase, enantiomer separation, highperformance liquid chromatography
