摘要
目的探讨糖皮质激素(GC)对狼疮性肾炎(LN)患者血清及肾内B淋巴细胞刺激因子(BlyS)的影响。方法用ELISA法和免疫组化法检测LN患者与正常对照者的血清和肾内BlyS的表达水平。结果 LN患者血清及肾内BlyS的表达水平显著高于正常对照者(P<0.001);GC治疗>2周组的LN患者肾内BlyS的表达水平及系统性红斑狼疮疾病活动性指数(SLEDAI)评分较未治疗组显著减少(P分别为0.012和0.005)。结论 GC减轻LN患者疾病活动性的作用可能与其降低肾内BlyS水平有关。
Objective To investigate the effect of glucocorticoid（GC） on the serum
and intrarenal expression of B lymphocyte stimulator（BlyS） in patients
with lupus nephritis（LN）.Methods The serum and intrarenal expression of
BlyS was respectively detected by ELISA and immunohistochemistry in LN
patients and normal controls.Results The serum concentration and
intrarenal production of BlyS in LN patients were significantly higher
than that in normal controls（P〈0.001）.The intrarenal production of BlyS
and the serum SLEDAI scores in LN patients that have received GC
therapy more than 2 weeks were obviously lower than those in LN
patients that haven′t received any treatment（P=0.012,0.005）.Conclusion
The effect of GC therapy on disease activity in LN patients may
associate with the decreasing expression level of intrarenal BlyS.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2012年第8期572-574,共3页
The Chinese Journal of Clinical Pharmacology
