摘要
目的:比较国产与进口罗库溴铵用于颈椎外伤手术全麻气管插管的成本-效果。方法:将拟在气管插管全身麻醉下行择期手术的颈椎外伤患者30例随机均分为国产罗库溴铵组和进口罗库溴铵组,2组分别应用国产或进口罗库溴铵进行麻醉诱导。观察并记录2组的肌松作用指标及不良反应,比较其经济性。结果:2组患者起效时间、单个颤搐刺激反应强度最大阻滞程度、气管插管条件比较,差异均无统计学意义(P>0.05)。2组均未见明显不良反应发生。国产罗库溴铵成本-效果比(0.850)显著低于进口罗库溴铵(0.959,P<0.05)。结论:国产与进口罗库溴铵均可提供良好的气管插管条件,2组具有相似的肌松起效时间,且安全性较好,但国产罗库溴铵较为经济。
OBJECTIVE： To compare the cost-effectivness of domestic rocuronium vs. imported rocuronium in patients under- went general anesthesia and tracheal intubation of cervical vertebral injury surgery. METHODS： 30 cervical vertebral injury patients undergoing surgery under tracheal-intubation general anesthesia were randomly divided into domestic rocuroniurn group and import- ed rocuronium group. 2 groups were given domestic rocuronium and imported rocuronium to induce anesthesia, respectively. The muscle-relaxing effect index and adverse drug reaction of 2 groups were observed and recorded. RESULTS： There were no signifi- cant differences in the on-set time, the maximal blockade extent of single ballism reaction, intubation conditions between 2 groups （P〉0.05）. There were no adverse reactions in 2 groups. The cost-effectivness of domestic rocuronium （0.850） was lower than that of imported rocuronium （0.959） significantly （P〈0.05）. CONCLUSION： Domestic rocuronium and imported rocuronium can provide sound intubation conditions. They have similar onset time and safety, but domestic rocuronium is more economical than other one.
出处
《中国药房》
CAS
CSCD
2012年第32期3000-3002,共3页
China Pharmacy
关键词
罗库溴铵
神经肌肉阻滞
颈椎外伤
成本-效果
Rocuronium
Neuromuscular blockade
Cervical vertebral injury
Cost-effectivness
