摘要
目的 :探讨抑癌基因 P1 6 和 P2 1 的表达在鼻腔鼻窦恶性肿瘤中的意义。方法 :用免疫组化 SP法检测了 6 0例鼻腔鼻窦恶性肿瘤 ,10例良性肿瘤 ,2 0例无瘤组织的 P1 6、P2 1基因的表达情况。结果 :鼻腔鼻窦恶性肿瘤组织的 P1 6、P2 1蛋白阳性率低于良性肿瘤及无瘤组织相应的阳性率 ,差异有统计学意义 (P <0 .0 5 )。 P1 6 、 P2 1 蛋白的改变为非相关性事件。结论 :P1 6 、 P2 1基因表达与鼻腔鼻窦恶性肿瘤的发生密切相关 ,且作用是相互独立的 ,与该肿瘤患者性别、年龄、组织来源、局部浸润及转移等因素无关。
Objective:To study the sifnigincane of P 16 and P 21 tumor suppressor expression in sinonasal maliganant tumors Methods:60 cases of sinonasal maliganant tumors,10 cases of benign tumors and 20 cases of tumor free sinonasal mucosa were detected for expression of P 16 ,P 21 genes by immunohistochemistry S p techique Results:Positive rates of P 16 ,P 21 proteins in sinanasal maliganant tumors were lower than that of benign tumors and tumor free mucosa Rates comparison between groups revealed sifnigicant difference (P<0 05) Expression of P 16 ,P 21 genes didn't correlate with the sex,age,tissue (P<0 05) The change of P 16 and P 21 protein in sinonasal maliganant was not relationship Conclusion:There was significant relationship between P 16 ,P 21 genes expressions and genesis of the sinonasal maliganant tumors and the effect was independent It had relationship with the sex,age,tissue origin,local etching and diversion of sinonasal maliganant tuomor patients
出处
《广西医科大学学报》
CAS
2000年第1期22-25,共4页
Journal of Guangxi Medical University
关键词
鼻腔鼻窦恶性肿瘤
P16蛋白
P21蛋白
基因表达
sinonasal maliganant tumor
tumor suppressor
P^(16) protein
P^(21) protein
immunohistochemistry
