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盐酸羟考酮缓释片直肠给药治疗中重度癌痛的疗效观察 被引量:1

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摘要 目的观察盐酸羟考酮缓释片(奥施康定)直肠给药治疗中重度癌痛的疗效及不良反应。方法奥施康定起始剂量10mg/12h,根据疼痛缓解程度进行剂量滴定。用药过程中疼痛未缓解、每日爆发痛次数超过2次,则增加下一次给药剂量,每次在原有基础上增加25%~50%,不增加给药次数。评价镇痛效果及不良反应。结果疼痛完全缓解5例(23.8%),明显缓解11例(52.4%),中度缓解3例(14.3%),轻度缓解2例(9.5%),总缓解(中度缓解+明显缓解+完全缓解)19例(90.5%)。不良反应以便秘为最常见,大多数不良反应轻微,对症处理即可,部分不良反应继续用药后消失。结论盐酸羟考酮缓释片直肠给药治疗重度癌痛亦可取得了较好的镇痛效果。
出处 《疾病监测与控制》 2012年第7期431-432,共2页 Journal of Diseases Monitor and Control
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