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辛伐他汀与氯沙坦对1型糖尿病大鼠心肌组织Toll样受体4和核因子-κB表达的影响 被引量:5

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摘要 Hamby等在1974年研究发现不合并冠心病的2型糖尿病患者也可出现充血性心力衰竭,据此,Hamby首次提出了糖尿病心肌病(DCM)的概念。DCM是由心脏对糖尿病的急性反应而导致的慢性病理过程,包括基因表达异常、信号转导的改变和细胞死亡;高血糖症是糖尿病心血管并发症的主要病因,炎症反应也起重要作用。
作者 钟媛 刘素筠
出处 《中国药物与临床》 CAS 2012年第8期1023-1026,共4页 Chinese Remedies & Clinics
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