摘要
50日龄健康岭南三黄肉鸡24只随机分为2组,雌雄各半.分别进行单剂量(10 mg.kg-1)静注和内服洛克沙胂的药物动力学(简称药动学)研究.以反相高效液相色谱法测定血浆中洛克沙胂质量浓度,采用WinNonlin 5.2药动学软件的非房室模型统计矩原理分析药物质量浓度-时间数据.鸡静注给药后主要药动学参数为:t1/2β=(2.37±0.11)h,Vz=(5.29±0.37)L.kg-1,AUC0-∞=(6.55±0.28)mg.L-1.h,CL=(1.56±0.07)L.h-1.kg-1.内服给药的主要药动学参数为:t1/2β=(3.02±0.08)h,tmax=(1.00±0.07)h,Cmax=(1.09±0.08)mg.L-1,AUC0-∞=(2.30±0.10)mg.L-1.h,MRT=(2.44±0.13)h,F=(35.28±1.0)%.洛克沙胂在鸡体内的药动学特征表现:静注分布较为广泛,消除迅速;内服给药后,吸收较快但不完全,生物利用度较低.
The pharmacokinetics of roxarsone was investigated by following single intravenous （ i. v. ） and oral administration both at a dosage of 10 mg/kg in healthy chickens. 24 chickens were randomly divided into two groups for experiments. Blood samples were collected at different intervals after administration of roxarsone. The concentrations of roxarsone in plasma were determined by high performance liquid chromatography （HPLC）. Plasma concentration-time profiles of roxarsone were analyzed by using non-compartmental analysis WinNonlin 5.2 software. The main pharmacokinetic parameters of i. v. administration were as follows： t1/2β= （2.37 ±0.11） h, Vz = （5.29 ±0.37） L . kg-1, AUC0-∞ = （6.55_±0.28） mg . L - 1 . h, CL = （ 1.56 ± 0. 07 ） L . h - 1 kg-1. The main pharmacokinetic parameters of oral adminis- tration were as follows： t1/2β= （3.02 ± 0. 08 ） h, tmax = （ 1. 0 ± 0. 07 ） h, Cmax ： （ 1. 09 ± 0. 08 ） mg·L-1,AUC0-∞ = （2. 30±0.10） mg·L-1 h, MRT=（2.44_0.13） h,F=（35.28±1.0）%. The results showed that the pharmacokinetic characteristics of roxarsone in healthy chicken manifested wide distribution, rapid elimination as well as incomplete absorption and low oral bioavailability.
出处
《华南农业大学学报》
CAS
CSCD
北大核心
2012年第3期403-406,共4页
Journal of South China Agricultural University
基金
公益性行业(农业)科研专项(200903055)
