摘要
目的探讨围绝经期女性血尿酸（UA）水平与颈动脉粥样硬化的关系。方法经颈动脉彩色多普勒超声检查233例围绝经期女性颈动脉内膜．中层厚度（IMT），根据测量结果分为颈动脉粥样硬化组（71例）和正常组（162例），比较两组血UA等相关指标的差异，并分析颈动脉粥样硬化的影响因素。结果颈动脉粥样硬化组血UA显著高于正常组[（341±86）μmol／L比（293±78）μmol／L]（P〈0．05）；正常组高尿酸血症检出率为10．49％（17／162），颈动脉粥样硬化组为40．85％（29／71），两组比较差异有统计学意义（P〈0．01）。Pearson相关分析显示，颈动脉粥样硬化与年龄（r=0．233，P=0．028）、体质指数（BMI）（r=0．215，P=0．044）、血UA（r=0.249，P=0．019）、空腹血糖（r=0．214，P=0．046）呈正相关，与高密度脂蛋白胆固醇呈负相关（r=-0．224，P=0．036）。Logistic回归分析显示，在校正了年龄、BMI等影响因素后，颈动脉粥样硬化程度仍与血UA存在显著相关性（OR=4．805，95％CI1．700—11．673，P〈0．05）。结论高尿酸血症是围绝经期女性颈动脉粥样硬化发生的相关危险因素。
Objective To observe the relationship between blood uric acid （UA） level and carotid atherosclerosis （CAS） in perimenopausal women. Methods Two hundred and thirty-three perimenopausal women were selected. Intima media thickness （IMT） of bilateral carotid arteries were measured by colour Doppler ultrasound. They were divided into normal group（ 162 cases） and CAS group （71 cases） according to the results of colour Doppler ultrasound. The level of blood UA between two groups was compared and the influence factors of CAS were analyzed. Results The level of blood UA in CAS group was significantly higher than that in normal group [ （341 ± 86） μ mol/L vs. （293 ± 78 ）μ mol/L ] （P 〈 0.05 ）. The detection rate of hyperuricemia in normal group was 10.49%（17/162） ,while the detection rate in CAS group was 40.85% （29/71）,which had statistical significance between two groups （P 〈 0.01 ）. Pearson correlation analysis showed that CAS had positive correlation with age （r = 0.233, P = 0.028 ）, body mass index（BMI）（r= 0.215, P= 0.044）, blood UA （r = 0.249,P= 0.019） and fasting plasma glucose （r = 0.214,P = 0.046）. And CAS was negatively correlated with high density lipoprotein cholesterol （r =-0.224,P = 0.036）. Logistic regression analysis showed that after the factors of age and BMI were corrected, CAS still had significantly positive correlation with the level of blood UA（OR = 4.805,95% CI 1.700 - 11.673 ,P 〈 0.05 ）. Conclusion Hyperuricemia is a related risk factor of the incidence of carotid atherosclerosis in perimenopausal women.
出处
《中国医师进修杂志》
2012年第21期23-25,共3页
Chinese Journal of Postgraduates of Medicine
关键词
围绝经期
尿酸
颈动脉疾病
Perimenopause
Uric acid
Carotid artery diseases
