摘要
1例29岁女性为减肥自行服用盐酸二甲双胍500 mg,3次/d。约1年后出现发热伴上腹部不适、呕吐、尿黄、陶土样大便。肝功能检查:丙氨酸转氨酶(ALT)782 U/L,天冬氨酸转氨酶(AST)346 U/L,总胆红素26μmol/L,C反应蛋白23 mg/L。停用盐酸二甲双胍,给予保肝治疗。15 d后复查肝功能:ALT 65 U/L,AST 50 U/L。
A 29-year-old female self-administered metformin hydrochloride 500 mg thrice daily to lose weight. About one year later, she developed fever, upper abdominal pain, vomiting, yellowish urine, and clay-like stool. The liver function tests revealed the following levels ： alanine aminotransferase （ALT） 782 U/L, aspartate aminotransferase （AST） 346 U/L, total bilirubin 26 p, mol/L, C- reactive protein 23 mg/L. Mefformin hydroehloride was withdrawn and liver-protective treatment was given. Fifteen days later, repeat liver function tests showed an ALT level of 65 U/L and an AST level of 50 U/L.
出处
《药物不良反应杂志》
2012年第3期167-168,共2页
Adverse Drug Reactions Journal
关键词
二甲双胍
肝炎
药物性
metformin
hepatitis, drug-induced
