摘要
目的:分析研究倍他司汀治疗椎基底动脉供血不足的临床疗效及安全性。方法:将76例椎基底动脉供血不足患者随机分为治疗组和对照组各38例,均于发病24小时内治疗,对照组给予静滴丹参注射液20ml,治疗组给予静滴倍他司汀40mg,两组均1次/日,治疗10天,治疗前后用经颅多普勒(TCD)测定椎动脉(VA),基底动脉(BA),大脑后动脉(PCA)血流速度。结果:治疗组总有效率94.74%,对照组总有效率78.95%,两组比较差异有统计学意义(P<0.05);TCD检查治疗组用药后VA等血流速度与用药前比较明显改善,与对照组比较,差异有统计学意义(P<0.05)。结论:倍他司汀可以缓解脑血管痉挛及改善脑动脉的血流量,治疗椎基动脉供血不足疗效明显,优于丹参注射液,且不良反应少。
Objective： To observe the thera- peutic effect of betahistine on vertebrobasilar insufficiency （VBI）. Methods ： 76 VBI pa- tients were divided randomly into therapeu- tic group and control group each in 38 ca- ses, all of whom received treatment within 24 h after VBI seizure. In control group,20 ml danshen injection was given intravenn- ously once a day,for 10d. In the therapeutic group ,betahistine 40 mg was given intraven- nously once a day,for 10d. The tachography was performed in two groups, including mean blood flow velocity of vertebral artery （VA） , basilar artery （ BA ） , posterior cere- bral artery （ PCA ） , by transcranall Doppler ultresonography before and after treatment. Results：The total effective rate in the thera-peutic group （ 94. 74% ） was significantly higher than in control group（78.95% ） （P 〈 0.05 ）. In the therapeutic group ,the mean blood flow velocity of VA, BA and PCA were obviously improved after treatment compared with post - therapeutic control group（ P 〈 0. 05 ）. Conclusion：The betahistine has good clinical effect on vertebrobasilar artery insuf- ficiency vertigo with compare of danshen in- jection.
