摘要
目的探讨泮托拉唑联合伊托比利治疗反流性食管炎的临床疗效。方法将208例确诊为反流性食管炎的患者随机分为2组,各109例,治疗组给予泮托拉唑联合伊托比利,对照组给予雷尼替丁联合伊托比利,分别于治疗前、治疗后4周及8周,观察2组患者临床症状及胃镜下变化。结果治疗后4周及8周,治疗组临床症状总有效率及胃镜下食管粘膜病损愈合率均优于对照组(P<0.01)。结论泮托拉唑联合伊托比利治疗反流性食管炎优于雷尼替丁联合伊托比利,是一种安全可靠、疗效显著的治疗方法,值得临床进一步推广。
Objective To investigate the clinical efficacy of the pantoprazole combined with itopride for reflux esophagitis. Methods A total of 208 patients with confirmed reflux esophagitis were equally randomized into treatment and control groups. The treatment group received pantopra- zole combined with itopride, while the control group took ranitidine combined with itopride. The clinical symptoms and endoscopic changes in the two groups were observed before treatment, and 4 weeks and 8 weeks after treatment. Results The overall response rate and healing rate of endoscop- ic esophageal mucosal lesion were better in the treatment group than in the control group 4 and 8 weeks after treatment （P 〈 0.01）. Conclusion reflux esophagitis is safe, reliable and effective, worthy of wider application. The pantoprazole in combination with itopride for superior to ranitidine combined with itopride, and
出处
《实用临床医药杂志》
CAS
2012年第9期64-66,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220012)
