摘要
目的:研究肥胖大鼠铁代谢和铁营养状态,为防治肥胖性铁营养不良提供理论依据。方法:将27只雄性Wistar大鼠随机分为对照组(n=10)和肥胖组(n=17),分别喂养普通饲料和高脂饲料,12周后眼球取血处死。全血测定血红蛋白、红细胞数、血细胞压积;血清测定血清铁、总铁蛋白结合力、血清转铁蛋白饱和度、铁调素、转铁蛋白及铁蛋白。结果:与对照组比较,肥胖组大鼠红细胞总数、红细胞压积值升高,血红蛋白含量降低,其中红细胞总数与对照组比较差异有统计学意义(P<0.05)。肥胖组大鼠血清铁、铁饱和度降低,血清总铁结合力升高,其中血清铁、铁饱和度水平与对照组比较差异有统计学意义(P<0.05);肥胖组大鼠铁蛋白、铁调素、转铁蛋白降低,其中铁蛋白、铁调素水平与对照组比较差异有统计学意义(P<0.05)。结论:肥胖会导致铁营养不良,引起铁代谢指标的改变。肥胖者应注意补充铁的摄入。
Objective To study the iron metabolism and iron nutrition state in obesity rats,and to provide the evidence for the prevention and control of iron malnutrition induced by obesity.Methods 27 male Wistar rats were divided into control group（n=10）and obesity group（n=17）,the rats were fed with ordinary feed,high fat diet,respectively for 12 weeks,then they were killed by taking the eye blood.The hemoglobin,red cell count,hematocrit,serum iron,total iron binding capacity,serum transferrin saturation,hepcidin,transferring and ferritin of rats were determined.Results Compared with control group,the red cell count and hematocrit value in obesity group were increased,the hemoglobin content was decreased,in which the red blood cell number compared with control group showed significant differences（P〈0.05）.The serum iron,iron saturation values in obesity group were lower,the serum total iron binding capacity was increased,including serum iron,the iron saturation value compared with control group showed significant differences（P〈0.05）.The ferritin,transferrin and hepcidin values in obesity group were reduced.Wherein,the hepcidin and ferritin values compared with control group had significant difference（P〈0.05）.Conclusion Obesity can lead to iron malnutrition and the changes of iron metabolism indices.The obesity subjects should pay attention to iron deficiency.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2012年第4期721-724,共4页
Journal of Jilin University：Medicine Edition
基金
吉林省卫生厅科研基金资助课题(2011Z056)
