摘要
弗林蛋白酶(Furin)是前体蛋白转化酶家族的重要成员之一,广泛存在于各种组织和细胞系中。Furin经过两次自剪切去掉前肽后具有生理活性,能够识别特定的氨基酸序列并在TGN中对多种前体蛋白进行加工。Furin的作用底物不仅包括神经肽和肽类激素,还包括许多生长因子、受体、血浆蛋白酶、基质金属蛋白酶及细菌外毒素等,具有重要的生物学功能。
Furin is a key member of the family of proprotein convertases, which is expressed in all tissues and cell lines. It will gain its bioactivity after two self-cleavages and activate many of her proproteins into their biologically active forms in the trans-Golgi net- work, because it can identify the specific amino acid sequence. Furin possesses important biological functions as it is capable of cleaving precursors of a wide variety of proteins, not only neuropeptides and peptide hormones, but also many growth factors,receptors, plasma proteases, matrix metalloproteinases and bacterial exotoxins.
出处
《现代生物医学进展》
CAS
2012年第18期3586-3588,共3页
Progress in Modern Biomedicine
基金
福建省自然科学基金资助项目(2009J01127)
