摘要
目的:探讨骨桥蛋白在不同分期糖尿病肾病患者肾组织的表达及其临床意义。方法:用免疫组化方法检测无糖尿病肾病组(N=20)、早期糖尿病肾病组(n=20)、临床糖尿病肾病组(n=20)肾组织骨桥蛋白的表达情况。结果:在不同分期糖尿病肾病组的骨桥蛋白表达不同,无糖尿病肾病组骨桥蛋白表达最低,临床糖尿病肾病组骨桥蛋白表达最高。结论:骨桥蛋白可能是糖尿病肾病的重要发病因素之一,抑制糖尿病患者肾脏骨桥蛋白的表达,可能延缓糖尿病肾病的进展。
Objective：To explore the expression and clinical significant of osteopontin （OPN） in patients with different stages of diabetic nephropathy. Methods：Immunohistochemistry were used to detect the protein expression of OPN in no diabetic nephropathy group（n=20）, early diabetic nephropathy group（n=20）and clinic diabetic nephropathy group （n=20）. Results：The expression of OPN was different with the progress of diabetic nephropathy, the expression of OPN increasing, minimum expression in no diabetic nephropathy group, and highest in clinical diabetic nephropathy group. Conclusions：OPN may be one of the important pathogenic factors in patients with diabetic nephropathy. It can delay the progress of diabetic nephropathy by inhibiting OPN expression.
出处
《岭南急诊医学杂志》
2012年第3期184-186,共3页
Lingnan Journal of Emergency Medicine
关键词
骨桥蛋白
糖尿病肾
表达
osteopontin
diabetic nephropathy
expression
