摘要
目的采用磁共振波谱成像技术检测应用奥拉西坦及放疗前后脑组织内相关因子(NAA,Cr,Cho)等含量的变化,探讨奥拉西坦在预防放射性脑病中的作用。方法随机选择2006年1月至2008年1月期间,行放射治疗的头颈部及颅内肿瘤患者82名,男性49例,女性33例,年龄18～76岁,平均年龄58±3.12岁。分为治疗组与对照组两组,对照组放疗加或不加肾上腺皮质激素(36例);治疗组放疗加奥拉西坦(46例)。结果对照组和治疗组患者常规MRI检查放疗前后MRI均显示无脑实质内形态学明显异常。MRS检查对照组放疗结束时双侧颞叶Cho/Cr明显升高。结论奥拉西坦有可能减少、预防放射性脑损伤的发生。
Objective To explore the preventive effect of Oxiracetam on the radiation encephalopathy. Methods 82 cases with head and neck or intracranial tumor were randomly divided into two groups： the treatment group were treated with radiotherapy plus Oxiracetam, the control group were treated with single radiotherapy. The content of NAA, Cr, or Cho in brain tissue were detected by magnetic resonance spectroscopy. Results No significantly morphology diffrence were observed in brain parenchyma before and after radiotherapy in both treatment group and control group. Howerver, in treatment group, Cho/Cr in bilateral temporal lobe after radioation was higher than before treatment. Conclusion Oxiracetam may prevent the occur of radiation encephalopathy.
出处
《脑与神经疾病杂志》
2012年第4期249-251,共3页
Journal of Brain and Nervous Diseases
基金
河北省医学重点科研资金资助项目(07088)
关键词
奥拉西坦
磁共振波谱成像
放射性脑损伤
Oxiracetam
Magnetic resonance spectroscopy（MRS）
Radiation encephalopathy
