摘要
乙二胺四乙酸盐(EDTA)是由国际血液学标准委员会(ICSH)建议作为血细胞分析较理想的抗凝剂,目前广泛应用于临床。但EDTA可使某些患者甚至健康人的血小板在体外发生聚集,从而导致血细胞分析仪测定的血小板数值假性减低,即EDTA依赖性假性血小板减少症(EDTA-dependent-pseudothrombocytopenia,EDTA-PTCP)。这种现象可引起临床的误诊、漏诊,对患者造成伤害,引发医疗纠纷。本文对EDTA-PTCP的临床特点、发病机制和临床诊断等相关内容加以综述,以期为阐明EDTA-PTCP的发病机制,明确其诊断和避免误诊的发生提供思路。
Ethylenediaminetetraacetic acid is an ideal anticoagulant for analysis of blood cells,which is suggested by the International Council for Standardization in Haematology（ICSH）.Nowadays,EDTA is widely used clinically.However,this anticoagulant may lead to platelet aggregation in a few patient and even some healthy people in vitro.The phenomenon,that the platelet count is in a spuriously low condition with the anticoagulant EDTA,is called EDTA-dependent-pseudothrombocytopenia（EDTA-PTCP）.It may lead to misdiagnosis,subsequent mismanagement of patients and medical disputes,when the phenomenon is failed to be recognized.This article will review the clinical character,pathogenesis mechanism and clinical diagnosis of EDTA-PTCP.Those will give the clue for clarifying the mechanism,diagnosis of EDTA-PTCP and avoiding the occurrences of misdiagnosis.
出处
《基层医学论坛》
2012年第19期2551-2553,共3页
The Medical Forum
关键词
乙二胺四乙酸盐
抗凝剂
血小板减少
误诊
Ethylenediaminetetraacetic acid Anticoagulant Thrombocytopenia Misdiagnosis
