摘要
目的探讨冠状动脉粥样硬化性心脏病(冠心病)患者颈总动脉的内膜中层厚度(common carotid intima-media thickness,CIMT)和尿微量白蛋白水平同冠状动脉病变程度及形态之间的关系。方法冠状动脉造影证实的冠心病患者158例,检测CIMT和晨尿白蛋白与肌酐浓度比值(urinary albumin-to-creatintine ratio,UACR)。根据冠状动脉造影将患者分为单纯狭窄组和复杂狭窄组,比较两组CIMT和UACR。以冠状动脉狭窄程度为应变量(Y),而以患者年龄(X1)、总胆固醇(X2)、三酰甘油(X3)、高密度脂蛋白(X4)、低密度脂蛋白(X5)、UACR(X6)及CIMT(X7)作为自变量,进行多因素逐步回归分析。结果复杂狭窄组CIMT[(1.06±0.27)mm vs.(0.92±0.19)mm,P<0.05]及晨UACR[0.69±0.36 vs.0.52±0.33,P<0.05]明显高于单纯狭窄组,差异有统计学意义。多因素逐步回归分析显示冠状动脉病变积分与UACR之间存在线性关系(Y=8.493-3.537X4+1.036 X6,F=4.851,P=0.037)。结论CIMT及尿微量白蛋白升高与冠心病患者的冠状动脉病变程度和形态有一定关系。
Objectives To investigate the relationships between common carotid intima-media thickness （CIMT） and urinary microalbumin with morphous of coronary lesion in patients with coronary artery disease. Methods A total of 158 patients with coronary artery disease were divided into complex stenosis group and simple stenosis group according to the results of coronary angiography. CIMT and urinary albumin-to-creatintine ratio （UACR） were detected and compared. Coronary stenosis index was taken as dependent variable （Y）,while age （X1）, total cholesterol （X2）, triglyceride （X3）, high density lipoprotein （X4）, low density lipoprotein （X5）, UACR （X6） and CIMT （XT） were taken as independent variable to carry out stepwise multiple linear regression analysis. Results There were significant differences between the patients with complex stenosis and those with simple stenosis in terms of CIMT [ （1.06±0.27） mm vs. （0.92±0.19） mm,P〈0.05] and morning UACR [0.69±0.36 vs. 0.52±0.33,P〈0.05]. Stepwise multiple linear regression analysis indicated that UACR had linear relationship with the coronary stenosis index （Y：8.493-3.537X4± 1.036 X6,F=4.851, P=0.037）. Conclusions The increased CIMT and UACR can contribute to the complex stenosis and the degree of coronary stenostic lesion in patients with coronary artery disease.
出处
《岭南心血管病杂志》
2012年第4期428-430,共3页
South China Journal of Cardiovascular Diseases
关键词
冠状动脉疾病
颈动脉内膜中层厚度
尿微量白蛋白
冠状动脉造影
coronary artery disease
common carotid intima-media thickness
urinary microalbumin
coronary angiography
