摘要
3,5-二羟基苄醇经氯代、氰化和羟基保护制得3,5-二(甲氧甲氧基)苯乙腈(5),5和4-甲氧甲氧基苯甲醛(6)在微波辐照下经缩合、水解及脱羧,然后脱保护基得到白藜芦醇,总收率约56%(以3,5-二羟基苄醇计)。
Resveratrol was synthesized from 3,5-dihydroxybenzylalcohol by chlorination, cyanidation and hydroxyl group protection to give 3,5-bis （methoxymethoxy） phenylacetonitrile （5）, which was subjected to condensation with 4-methoxymethoxybenzaldehyde （6）, hydrolysis, decarboxylation and deprotection under microwave irradiation with an overall yield of about 56 % （based on 3,5-dihydroxybenzylalcohol）.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2012年第8期656-657,672,共2页
Chinese Journal of Pharmaceuticals
基金
重庆市科技攻关计划项目(2011AC5106)
关键词
白藜芦醇
微波辐射
合成
resveratrol
microwave irradiation
synthesis
