摘要
目的:探讨黄芪注射液对慢性阻塞性肺病(COPD)急性加重期患者氧化应激和炎性介质的影响。方法:COPD急性加重期患者47例随机分成两组(A组和B组),A组24例,平均(63.27±6.22)岁,给予综合治疗加3次/周静脉注射黄芪注射液10 ml(相当于黄芪20 g);B组23例,平均(61.53±6.78)岁,给予综合治疗,未予黄芪治疗,总观察时间为14 d;C组18例,为年龄、性别匹配的健康对照组。检测氧化应激指标(MDA、SOD)和炎性介质(CRP、IL-6)水平并比较分析。结果:COPD急性加重期患者血浆的MDA、CRP、IL-6水平明显高于对照组,差异有统计学意义(P<0.01),SOD显著低于对照组,差异有统计学意义(P<0.01);A组治疗前后MDA、IL-6及SOD水平比较,差异有统计学意义(P<0.01或P<0.05)。结论:黄芪注射液能改善COPD急性加重期患者的氧化应激和炎性反应状态。
Objective To investigate the influence of injection huang qi on oxidative stress and inflammation mediator in chronic ob- structive pulmonary disease（COPD） acute exacerbation patients. Method 47 COPD acute exacerbation patients were randomly divided into two groups （A group,n =24 and B group,n =23）. Group A,aged （63.27±6.22 years） ,was treated by ordinary method and 10ml of in- jection huang qi intravenously three times per week, while group B, aged （61.53±6.78 years） was not treated by injection Huang qi. Tile total observation period was 14 days. 18 age and sex matched healthy volunteers served as control. Indexes related with oxidative stress [ ma- londialdehyde（MDA） and superoxide dismutase（SOD） ] and inflammation mediator[ C - reactive protein（CRP） and interleukin - 6 （ IL - 6） ] were measured and analyzed. Results Levels of the blood plasma MDA, CRP and IL - 6 in COPD acute exacerbation patients were higher than those of control （ P 〈 0. 01 ）, while SOD levels were lower than control （ P 〈 0. 01 ） ; compared with after treatment, levels of blood plasm MDA, CRP and IL - 6 in A groups were significantly lower （ P 〈 0. 01 ） ; SOD levels were significantly higher （ P 〈 0. 05 ）. Conclusion Injection Huang qi can relieve the oxidative stress and inflammation state in COPD acute exacerbation.
出处
《吉林医学》
CAS
2012年第20期4259-4261,共3页
Jilin Medical Journal
关键词
慢性阻塞性肺病
氧化应激
炎性反应介质
黄芪注射液
Chronic obstructive pulmonary disease
Oxidative stress
Inflammation mediator
Injection Huang qi
