摘要
采用以乳酸乙酯、溴代丁二酰亚胺和盐酸羟胺为原料的新工艺,制备了溴代丙酮酸乙酯肟。通过溴代和氧化反应过程中生成的溴代丙酮酸乙酯粗品不需分离,在氯仿和甲醇混合溶剂中,直接与盐酸羟胺缩合,经处理得白色结晶,收率为48%;通过温和的酯化反应,首次合成其衍生物3-溴-1-萘甲酰亚胺基丙酸乙酯(3),并通过了1HNMR,13C-NMR和元素分析等表证。
Ethyl-hydroxyimino-bromopropanoate was prepared from ethyl lactate, NBS and hydroxyla- mine hydrochloride in a novel method. In the reaction process, intermediate ethyl bromopyruvate was obtained by bromination and oxidation, instead of being separated from the reaction mixture and directly used to react with hydroxylamine hydroehloride in CHC13 and CH3OH solution. The white crystal product was obtained in 48% yield. The new derivative ethyl-3-bromo-2- （1-naphthoyl-oximino） propanoate was synthesized successfully via the mild esterification reaction. The target compound was characterized b ^1HNMR, ^13C-NMR and elemental analysis.
出处
《中山大学学报（自然科学版）》
CAS
CSCD
北大核心
2012年第4期144-146,共3页
Acta Scientiarum Naturalium Universitatis Sunyatseni
基金
广东省科技计划资助项目(2010B060900084)
中国博士后基金资助项目([2010]07)
广东药学院博士启动基金资助项目(2006YKX11)
