摘要
目的为开展药物新剂型研究提供参考。方法查阅相关专业文献,对微球给药系统的制备方法及质量评价进行综述。结果微球给药系统的制备方法有溶剂挥发法、喷雾干燥法、乳化交联法。微球给药系统的质量评价包括形态及粒径分布、载药量及包封率、微球的释放速率、稳定性等。结论微球给药系统作为一种新剂型,近年来受到广泛关注,具有广阔的发展前景。
Objective To privide referrences for new fornmlations of drugs. Methods To access to the related professional literatures, and to review the preoaration methods and quality of evaluation microsphere drug delivery system. Results The preparation method of micro- sphere drug delivery systems by solvent evaporation, spray drying, emulsification crosslinking method are introduced. Evaluate the quality of the microsphere delivery system, including the morphology and size distribution, drug loading and entrapment efficiency, release rate, sta-bility of the microspheres. Conclusion Microsphere drug delivery system as a new dosage form, attracted widespread attention in recent years, has a broad development prospects.
出处
《中国药业》
CAS
2012年第13期1-2,共2页
China Pharmaceuticals
基金
重庆市教委立项课题
项目编号:KJ102501
关键词
微球给药系统
制备方法
质量评价
microsphere drug delivery system
preparation methods
quality evaluation
