摘要
目的：探讨肝细胞癌（ＨＣＣ）的ＭＲ信号特征与癌组织病理分级、ＤＮＡ含量之间的关系。方法：用ＤＥＮ诱导大鼠ＨＣＣ，于不同时相点观察其ＭＲ信号变化，并对其细胞核ＤＮＡ含量做相应的定量分析。结果：共诱发５１个ＨＣＣ，Ｔ_２ＷＩ均呈高信号，Ｔ_１ＷＴ呈高（１０／５１）、等（９１５）、低（３２／５１）信号，其中高信号者于诱癌早期多见，病理上多为Ⅰ、Ⅱ级，低信号者以晚期多见，主要为Ⅲ、Ⅳ级。随着高信号向低信号的演变ＤＮＡ含量呈增加趋势。结论：在ＨＣＣ的演进过程中其Ｔ_１ ＷＩ信号遵循由低到高的规律，从ＭＲ信号特征可间接判断ＨＣＣ的恶性程度。
Objective: To study the relationship of signal pattern on MRI and pathologic grading and nuclear DNA content in hepatocellular carcinoma (HCC ). Methods: HCC was induced in rats by DEN.On different time phases MR examinations were per- formed. The nuclear DNA contents were quantitatively analyzed with an imaging analyzer, Results:51 lesions were detected.On T_2 WI images all lesions appeared hyperinitense.On T_1 - Weighted images they showed various signal patterns, including hyperintensity (10/51), isointensity (9/51) and hypointensity (32/51).The lesions with hyperintensity were found mostly in the early phases, and pathologicaly graded as Fdmonson Ⅰ - Ⅱ. Hypointense HCC were found mostly in later phases, and accounted for most Ⅲ-Ⅳ HCC. With the change of signal from hyperintensity to hypointensity, the nuclear DNA content in HCC tissue increased.Concl- usions:The malignancy grade of HCC can be determined indirectly by the signal pattern on T_1 - weighted images.
出处
《重庆医学》
CAS
CSCD
2000年第1期19-21,共3页
Chongqing medicine
关键词
肝细胞癌
磁共振成像
DNA含量
病理分级
Hepatocellular carcinoma Magnetic resonance imaging DNA content Pathologic grading
