摘要
以氯化苄和对氯苯甲醛为原料,通过格氏法合成4-氯苯基苄基醇,进一步经硅胶负载氯铬酸吡啶(PCC)氧化为成4-氯苯基苄基酮。总产率为75.0%。探讨多种因素对收率的影响,获得控制反应过程的最佳参数。通过IR、1 H NMR、13 C NMR对产物的结构进行了分析表征。
4--chlorophenylbenzylmethanol was synthesized via Grignard method using benzyl chloride and p--chlorobenzaldehyde as starting materials, subsequent oxidation by silica gel loaded pyridinium chlorodi-chromate afforded 4--chlorophenylbenzylketone with 75% overall yield. Various factors on the yield of products were explored, and the optimal parameters for controlling reaction processes were obtained. The molecular structures of the products were characterized using infrared, 1H and 1℃ nuclear magnetic reso-nance spectroscopy.
出处
《常州大学学报（自然科学版）》
CAS
2012年第2期31-34,共4页
Journal of Changzhou University：Natural Science Edition
关键词
4-氯苯基苄基醇
4-氯苯基苄基酮
格氏反应
氧化
4-- chlorophenylbenzylmethanol
4-- chlorophenylbenzylketone
Grignard reaction
oxidation
