摘要
目的:描述儿童青少年尿酸分布特征并分析尿酸与血糖、血脂水平关系,为进一步开展高尿酸相关疾病的早期预防提供理论依据。方法:采用分层整群抽样的方法,选择江苏省沭阳县农村和城镇各2所中小学年龄5～15岁的儿童青少年为研究对象。经调查对象家长知情同意后共有1 159人接受流行病学问卷调查获得一般人口学信息、行为生活方式资料,并测量身高和体重;共有971人接受血标本采集并检测尿酸(serum uric acid,UA)、空腹血糖(fasting glucose,GLU)、血清总胆固醇(totalcholesterd,TC)和甘油三酯(total triglyceride,TG)。按年龄、性别等人群特征分别描述尿酸水平分布并分析尿酸与血糖、血脂水平关系。结果:①线性相关分析显示,男性UA与GLU有统计学联系(r=-0.11,P=0.023),而与年龄、TC、TG、体质指数(BMI)均无统计学关联(P>0.05);女性UA与年龄、GLU有统计学联系(r=-0.09,P=0.039;r=0.18,P=0.004),而与TC、TG、BMI均无统计学关联(P>0.05);②进一步进行Logistic回归分析发现,男性UA升高与BMI有统计学关联,OR(95%CI)值为2.32(1.24～4.35),P=0.008;女性UA升高与年龄、GLU均有统计学关联,OR(95%CI)分别为0.90(0.84～0.96)、1.52(1.13～2.04)。结论:年龄、血糖及BMI可能是儿童青少年尿酸水平变化的重要影响因素,且男女之间存在显著差异。
Objective：To describe the epidemiological distribution of serum uric acid in children and adolescents, and to provide theoretical basis for early prevention of hyperuricemia-related diseases. Methods：Stratified cluster sampling method was used to select children and adolescents in the age group of 5-15 years in two rural and two urban township schools in Shuyang County, Jiangsu province. With written informed consent,a total number of 1 159 children＇s parents were interviewed,and the questionnaire included demographic information,behavior and lifestyles factors. Body height and weight of children were measured by physical examination at the same time of interview. Blood sampling and lab analysis on serum uric acid （UA）,fasting glucose （GLU）,total cholesterol （TC） and total triglyeeride （TG） were conducted among 971 subjects. Results：Significant negative linear correlation was found between UA and GLU （r = -0.11 ,P = 0.02） among males,whereas no relationship was observed between UA and age ,TC, TGand BMI（P 〉 0.05）. For females,UA was observed to be significantly correlated with age and GLU （r = -0.09,P = 0.039;r = 0.13, P = 0.00g）,but not with TC,TG and BMI （P 〉 0.05）. Logistic regression analysis indicated that UA elevation was associated with BMI among males,and was associated with age and GLU among females. The corresponding odds ratios （ORs） and 95% confidence intervals （95%Cis） were 2.32（1.24-4.35）,0.90 （0.84-0.96） and 1.52（1.13-2.04）. Conelusion：Age,GLU and BMI might be im- portant determinants of serum UA level of children and adolescents, and have significant differences between males and females.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2012年第6期882-886,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省预防医学基金资助(Y200707)
关键词
儿童青少年
尿酸
高尿酸血症
children and adolescents
serum uric acid
hyperuricemia
