摘要
目的探讨克罗米芬和吡格列酮治疗多囊卵巢综合征的临床疗效与安全性。方法 2008年4月—2011年3月诊治高胰岛素血症的多囊卵巢综合征患者共142例,随机分为对照组和治疗组,每组71例,对照组采用克罗米芬治疗,治疗组采用吡格列酮治疗,2组均治疗4个月,比较2组空腹血胰岛素水平、睾酮、促卵泡激素、排卵情况及不良反应发生率。结果接受治疗后2组的空腹血胰岛素水平、睾酮、促卵泡激素及排卵情况均较治疗前有显著改善(P<0.05);治疗组空腹血胰岛素水平、睾酮、促卵泡激素、排卵情况明显优于对照组(P<0.05)。治疗组不良反应发生率明显低于对照组(P<0.05)。结论克罗米芬、吡格列酮对于多囊卵巢综合征伴高胰岛素血症患者均有恢复排卵、促进月经正常的作用,但吡格列酮较克罗米芬更能有效地降低胰岛素水平且不良反应更小,更为安全有效。
Objective To treating polycystic ovary syndrome （ explore the efficacy and safety of clomiphene and pioglitazone for PCOS）. Methods A total of 142 patients with hyperinsulinemia PCOS admitted from April 2008 to March 201l were randomly divided into control and treatment group with 71 cases of each group. The control group was pioglitazone, and both of two groups were treated given clomiphene while the for 4 months, the fasting treatment group received blood insulin （ FINS ）, testosterone （T） ,follicle -stimulating hormone （FSH） ,ovulation and incidence of adverse reactions were compared between the two groups. Results After treatment,the FINS,T, FSH and ovulation significantly improved compared with pre - treatment （ P 〈 0.05 ）. The FINS, T, FSH, ovulation and incidence of adverse reactions in the treatment group were better than the control group （P 〈 0.05 ）. Conclusion Clomiphene and pioglitazone for patients with hyperinsulinemia PCOS have the role of restoring ovulation and promoting normal menstruation, however, pioglitazone is more effective than clomiphene in reducing insulin levels and it has fewer side effects.
出处
《河北医科大学学报》
CAS
2012年第6期652-654,共3页
Journal of Hebei Medical University
关键词
多囊卵巢综合征
氯米芬
吡格列酮
polycystic ovary syndrome
clomiphene
pioglitazone
