摘要
目的:评价芬太尼透皮贴剂治疗≥65岁的老年中、重度癌痛患者的疗效及安全性。方法:35例中重度癌痛患者按年龄随机分为两组:老年组15例年龄≥65岁;对照组20例年龄<65岁。两组均使用芬太尼透皮贴剂治疗,初始剂量从4.2mg开始,连续使用14天后评价疗效、生活质量变化及不良反应。结果:所有患者用药后止痛效果明显,其中老年组疼痛缓解有效率为86.7%,对照组疼痛缓解有效率为85%。两组之间有效率无显著性差异(P>0.05)。生活质量均明显提高,两组之间无统计学差异(P>0.05)。不良反应均较轻,主要为头晕,嗜睡,便秘,恶心,呕吐等,均能耐受。两组的不良反应无显著差异(P>0.05)。结论:芬太尼透皮贴剂治疗老年(≥65岁)的中重度癌痛患者方便,安全,有效,值得临床进一步推广应用。
Objective： To observe the analgesia therapeutic effect and security of Fentanyl transdermal system for patients（ I〉 65 years old） with moderate to severe cancer pain. Methods： Thirty-five patients with moderate to severe cancer pain were randomly divided into two groups according to their ages：15 patients（≥65 years old） in elderly group and 20 cases （ 〈 65 years old ） in control group. Both groups were treated with Fentanyl transdermal system with the initial dose of 4. 2mg. After 14 days of continuously use, the therapeutic efficacy, change of life quality and adverse reactions were evaluated. Results： The analgesic effect in all patients after treatment was obvious. The pain relief rate was 86.7% in the elderly group and 85% in the control group with no significant difference between these two groups. Total efficiency was not significantly different between these two groups （ P 〉 0. 05 ）. Qualities of life were significantly improved , but no significant difference between the two groups was observed（ P 〉 0. 05 ）. Mild adverse effects mainly in- eluded dizziness, drowsiness, constipation, nausea and vomiting were tolerable. The difference of adverse reactions between these two groups was not significant（ P 〉 0. 05 ）. Conclusion： It is a convenient, safe and effective way to apply Fentanyl transdermal system for patients（ ≥65 years old） with moderate to severe cancer pain and worthy of further promotion and application.
出处
《肿瘤预防与治疗》
2012年第4期249-252,共4页
Journal of Cancer Control And Treatment
关键词
老年癌痛患者
芬太尼透皮贴剂
不良反应
Elderly Cancer Patients
Fentanyl Transdermal System
Adverse Reactions
