摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征（obstructivesleepapnea～hypopneasyndrome。OSASHS）及OSAHS合并高血压患者血清氧化低密度脂蛋白（oxidizedlowdensitylipoprotein，OX—LDL）、总抗氧化能力（total—antoxidantcapability，T—AOC）水平的变化。方法选择OSAHS患者22例，OSAHS合并高血压患者24例；健康对照组24例，测定血清OX—LDL T-AOC水平。并与睡眠呼吸监测指标进行相关分析。结果与正常对照组比较，0sAHs组及OSAHS合并高血压组血清TAOC活性均降低（P〈0．05），OX—LDL浓度均升高（P〈0．01）。OSAHS及OSAHS合并高血压患者血清OX—LDL、T—AOC水平与反映睡眠呼吸暂停严重程度的指标有相关性（P〈0．01）。结论OSAHS患者存在OX—LDL、T—AOC水平的变化，且与其病情严重程度相关；氧化应激及氧化损伤在0sAHs合并高血压患者中更明显。
Objective To study the changes of serum oxidized low density lipoprotein （OX-LDL） and total-antoxidant capability （T-AOC） in patients with obstructive sleep apnea-hypopnea syndrome （OSAHS） and obsturctive sleep apnea-hypopnea associated hypertension （OSAHAHT）. Methods 22 patients with OSAHS and 24 patients with OSAHAHT were included in this study,24 healthy subjects were introduced as control group. The levels of serum OX-I.DL and T-AOC were measured. The correlation analysis were made among the serum levels of OX-LDL, T-AOC and the indices of polysomnography. Results The activities of T AOC are lower in patients with OSAHS and OSAHAHT than those in control group （ P 〈0.05） and the concentration of OX-LDL is higher in patients with （）SAHS and OSAHAHT than that in control group （ P 〈0.01）. The serum levels of OX-LDL,T AOC in patients with OSAHS and OSAHAHT are correlated significantly with the indices of polysomnography which reflect the severity of obstructive sleep apnea （ P 〈 0.01 ）. Conclusions There serum levels of OX-LDL, T AOC might be changed in patients with OSAHS, and the changes are related to the servity of the disease. The oxidative stress process is more severe in patients with OSAHAHT than in OSAHS.
出处
《国际呼吸杂志》
2012年第13期988-991,共4页
International Journal of Respiration
