摘要
目的探讨本院铜绿假单胞菌医院感染的分布特点及对抗菌药物耐药性的变化趋势,为临床合理用药提供依据。方法对2008年1月至2010年12月本院住院患者送检各类标本进行分离培养,采用VITEK-2 compact全自动微生物仪进行菌株鉴定,用K-B纸片扩散法检测对13种抗菌药物的敏感性。结果所分离的865株铜绿假单胞菌中,自痰液标本中检出最多(80.8%),主要分布在干部病房、肿瘤科、神经内科和呼吸内科。铜绿假单胞菌对13种抗菌药物的耐药率呈逐年上升趋势。阿米卡星和亚胺培南对铜绿假单胞菌具有较好的抗菌活性,耐药率分别为13.8%和13.4%,可作为治疗重症铜绿假单胞菌感染的首选。结论铜绿假单胞菌的感染和耐药情况日益严峻,应加强耐药性监测,根据药敏结果选择合适有效的抗菌药物,防止交叉感染,以减少耐药菌株的产生与传播。
Objective To investigate the clinical distribution and the change in drug resistance of Pseudomonas aeruginosa in our hospital, in order to provide the basis for rational use of drugs. Methods All kinds of samples from inpatient department from January 2008 to December 2010 were cultured, bacteria were identified by VITEK-2 compact automated microbiology system. The drug-sensitivity testing was performed to 13 antimicrobial agents by K-B methods. Results Among the 865 strains of Pseudomonas aeruginosa, the pathogens isolated from respiratory tract specimens were predominate （80.8%）, the main departments with hospital infection caused by Pseudomonas aeruginosa were senior officials inpatient ward, tumour department, neurology department and pneumology department. The drug resistance of Pseudomonas aeruginosa against 13 kinds of drugs all appeared an increasing trend year by year. The antibacterial activity of Amikaein and Imipenem to Pseudomonas aeruginosa were superior, with average resistance rates as 13.8% and 13.4% , which could be the first-chosen antibiotic for severe infection of Pseudornonas aeruginma. Conclusions Drug resistance and infection of Pseudomonas aeruginosa became more serious than before. Resistance surveillance, based on susceptibility of rational use of effective antibiotics should be strengthened, inorder to prenvent cross infections and reduce the Pseudornonas aeruginosa producing and spreading.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2012年第3期53-55,共3页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
关键词
铜绿假单胞菌
医院感染
耐药率
Pseudomonas aeruginosa
Nosocomial infection
Resistance rate
